How Is Sucrase Made

Sucrase is secreted by the tips of the villi of the epithelium in the small intestine. Its levels are reduced in response to villi-blunting events such as celiac sprue and the inflammation associated with the disorder. The levels increase in pregnancy, lactation, and diabetes as the villi hypertrophy.

What is sucrase enzyme made of?

Sucrase isomaltase is classified as a glucosidase enzyme due to its role in creating monomers from larger complex carbohydrates. SI is composed of two subunits: sucrase and isomaltase. These two subunits come from a polypeptide, having an N-Terminus and a C-Terminus.

Do humans produce sucrase?

Sucrose is hydrolyzed by the enzyme sucrase, an α-glucosidase in the human small intestine, to its component monosaccharides fructose and glucose. About 10–25% of the fructose is converted to glucose in the brush border of the upper gastrointestinal tract.