How Long Does Metolazone Last

When metolazone tablets are given, diuresis and saluresis usually begin within one hour and may persist for 24 hours or more. For most patients, the duration of effect can be varied by adjusting the daily dose. High doses may prolong the effect. A single daily dose is recommended.

What is the half-life of metolazone?

Bioavailability (%)Half-life (hours)Metolazone656-20Loop diureticsBumetanide80-901-1.5Furosemide47-64 (oral absorption is reportedly more variable in organ dysfunction and with gut-wall edema)0.5-2

How often can you take metolazone?

Adults—At first, 2.5 to 5 milligrams (mg) once a day. Your doctor may adjust your dose if needed.