How Much Spironolactone for Acne?

DOSAGES. The dosage of spironolactone for acne is 25-200 mg/day in one to two divided doses. A study that used 50 mg spironolactone twice a day on Days 5 through 21 of women's menstrual cycle had a high rate of success with low incidence of side effects (Harper, 2006).

Is 50 mg of spironolactone enough for acne?

Spironolactone will help with acne on the face, back, and chest. The majority of sides effects associated with spironolactone are dose dependent; low-dose therapy (25–50 mg daily) generally is well tolerated, and even 100 mg daily is not problematic in most cases.

Is 200 mg of spironolactone too much?

The maximum dose that has been reported for acne in the literature is also 200 mg/day, “which is considered a high dose,” says Dr. Marchbein, who is currently testing even higher doses because the drug is used at higher doses for other conditions.