How to Measure Degranulation?

Methods for the identification of mast cell degranulation have primarily used enzyme-linked immunosorbent assays (ELISAs) or colorimetric assays to measure preformed inflammatory mediators, such as histamine and β-hexosaminidase.

What is degranulation of mast cells?

Degranulation is a cellular process that releases antimicrobial cytotoxic or other molecules from secretory vesicles called granules found inside some cells. It is used by several different cells involved in the immune system, including granulocytes (neutrophils, basophils, and eosinophils) and mast cells.

What is mast cell?

A type of white blood cell that is found in connective tissues all through the body, especially under the skin, near blood vessels and lymph vessels, in nerves, and in the lungs and intestines.

Sarah Jenkins

Sarah Jenkins

Senior Technology Editor & AI Specialist

Sarah Jenkins is a veteran tech journalist with over 12 years of experience covering artificial intelligence, mobile innovations, and digital ethics. Her insights have appeared in leading technology publications worldwide.