In Indole Electrophilic Attack Occurs at?
If C-3 Position Is Occupied, Then Electrophilic Substitution Takes Place at C-2 and If Both of Them Are Occupied Then Electrophile Attacks at C-6 Position...
If C-3 position is occupied, then electrophilic substitution takes place at C-2 and if both of them are occupied then electrophile attacks at C-6 position. 3.1. 1 Protonation: Indole is a very weak base pKa -3.5. The nitrogen atom of indole gets easily protonated even in water (at pH = 7) giving 1H-indolium cation.
Why does electrophilic substitution of indole take place at C 3?
The most reactive position present in the indole ring is third carbon. This is more reactive towards the electrophilic substitution reaction and it is even highly reactive than benzene. The Vilsmeier-Haack formylation can take place at the third position of the indole. ...
What is meant by electrophilic attack?
Electrophilic substitution reactions are chemical reactions in which an electrophile displaces a functional group in a compound, which is typically, but not always, a hydrogen atom. ... Some aliphatic compounds can undergo electrophilic substitution as well.
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