In Vitro Permeation Study?

In Vitro permeation testing (IVPT) studies across biological membranes for formulations that are applied to the skin or in the eye are vital to guide product development and establish product bioequivalence.

What is permeation study?

Permeation studies aim to determine the kinetic profile of the drug which reflects the changes in concentration over time and diffusion through the skin. ... As the developed formulation is for topical ap- plication the permeation profile and drug concentration that crosses the barrier were determined.

What is in vitro release testing?

In vitro release testing (IVRT) is an important quality and performance parameter for evaluation of the topical semisolid formulations. Similar to the solid oral dosage forms, IVRT of semisolids can help during product development stages in identifying the critical formulation and manufacturing variables.