In Which Cell Does Ketogenesis Takes Place?

Ketogenesis occurs primarily in the mitochondria of liver cells. Fatty acids are brought into the mitochondria via carnitine palmitoyltransferase (CPT-1) and then broken down into acetyl CoA via beta-oxidation.

Does ketogenesis occur in cytoplasm?

Besides its role in the synthesis of ketone bodies, HMG-CoA is also an intermediate in the synthesis of cholesterol, but the steps are compartmentalised. Ketogenesis occurs in the mitochondria, whereas cholesterol synthesis occurs in the cytosol, hence both processes are independently regulated.

Does ketogenesis occur in adipose tissue?

A key factor in the regulation of ketogenesis is the availability of nonesterified long-chain fatty acids to the liver, which in turn is controlled by their release from adipose tissue. The enzyme responsible for the initiation of the hydrolysis of stored triacylglycerols to fatty acids is hormone-sensitive lipase.