Is an Effect of Opsonization?

Entry of opsonized pathogens into phagocytes may benefit or, paradoxically, harm the host. Opsonization may trigger antimicrobial mechanisms such as reactive oxygen or nitric oxide (NO) production but may also provide a safe haven for intracellular replication.

What effect does Opsonization have on phagocytosis?

The opsonins act as molecular beacons, allowing interaction with receptors on macrophages, monocytes, and neutrophils to enhance phagocytosis and elevate mechanisms of targeted organism destruction.

What is Opsonization caused by?

Mechanism of Opsonization and Types of Opsonins

Opsonization occurs through the binding of an opsonin to an epitope of the pathogen or dead cells. Immune cells and pathogens all have negatively charged cell membranes. This causes the phagocyte and pathogen to be repelled away from each other.