Is Doxorubicin Cardiotoxicity Reversible?

Because severe doxorubicin cardiotoxicity is reversible in some patients, aggressive supportive therapy is warranted.

How do you reduce cardiotoxicity of doxorubicin?

Delivery of doxorubicin in a PEGylated liposomal form decreases the circulating concentrations of free doxorubicin and result in selective uptake of the agent in tumor cells. Use of PEGylated liposomal doxorubicin has been shown to decrease the cardiotoxicity of this anthracycline, even at doses >500 mg/m² [64, 65].

Does doxorubicin cause cardiotoxicity?

Doxorubicin is a highly effective anticancer agent but causes cardiotoxicity in many patients. The mechanisms of doxorubicin-induced cardiotoxicity remain incompletely understood.