Is Malonic Acid Dehydrogenated?

Alexander Ross
Alexander Ross
• • 6 min read

Presumably the Dissociation of the Enzyme-Substrate Complex Takes Place When Succinic Acid Has Been Dehydrogenated to Fumaric Acid Fumaric Acid Fumarase Adds...

Is Malonic Acid Dehydrogenated?

Presumably the dissociation of the enzyme-substrate complex takes place when succinic acid has been dehydrogenated to fumaric acid

fumaric acid
Fumarase adds water to fumarate to form L-malate, which is a substrate to regenerate oxaloacetate with formation of the third NADH+H+ of the cycle per acetyl CoA. The activities of TCA cycle dehydrogenases can be stimulated by changes in Ca2+ levels that are evoked by altered functional activity.
, but since malonic acid cannot be dehydrogenated, it does not readily dissociate from the enzyme, and consequently prevents it from reacting with succinic acid.

How does malonic acid inhibit succinic dehydrogenase?

Malonate is a competitive inhibitor of the enzyme succinate dehydrogenase: malonate binds to the active site of the enzyme without reacting, and so competes with succinate, the usual substrate of the enzyme. ... It resembles the substrate succinate, without a -CH2-CH2 group required for dehydrogenation.

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Is malonic acid a competitive or noncompetitive inhibitor?

d) Fumarate is the product, and malonic acid is a noncompetitive inhibitor.

Alexander Ross

Alexander Ross

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Alexander Ross has covered the video game industry for a decade, writing deep dives on game design, esports tournaments, VR developments, and gaming culture.