Is Monoamine Oxidase Reversible?

The enzymes turn over approximately every two weeks. A few newer MAOIs, a notable one being moclobemide, are reversible, meaning that they are able to detach from the enzyme to facilitate usual catabolism of the substrate.

How do you reverse an MAOI?

There are no antidotes for MAOI toxicity. Hemodialysis is ineffective in removing the drug from the body. Rapid correction of hyperthermia is vital. Cooling by evaporative heat loss (wetting skin and creating air flow with fans) is an effective treatment.

Which is a reversible inhibitor of MAO A?

CX157 is the first RIMA with demonstrated reversible inhibition of MAO-A in the human brain (as assessed through its inhibition [¹¹C]clorgyline binding to MAO-A), for which brain MAO-A inhibition has been shown to be proportional to and predictable from plasma drug levels.