Is Perineural Invasion Dangerous?

"Perineural invasion" on biopsy means that there is an increased chance that cancer could spread out of the prostate, but Gleason grade and amount of cancer in the cores are more important. Even with perineural invasion your cancer could still be very curable depending on other factors.

How serious is perineural invasion?

What does it mean if my biopsy mentions that there is perineural invasion? Perineural invasion means that cancer cells were seen surrounding or tracking along a nerve fiber within the prostate. When this is found on a biopsy, it means that there is a higher chance that the cancer has spread outside the prostate.

How is perineural invasion treated?

Patients with perineural invasion carry a much higher risk for local and distant recurrence and may require more aggressive treatment including Mohs micrographic surgery and adjuvant radiation.