Is Pyrazinamide Soluble in Ethanol?

Pyrazinamide is soluble in organic solvents such as ethanol, DMSO, and dimethyl formamide, which should be purged with an inert gas. The solubility of pyrazinamide in these solvents is approximately 0.2, 30, and 25 mg/ml, respectively.

How is pyrazinamide administered?

Usual dose: Pyrazinamide is administered orally, 15 to 30 mg/kg once daily. Older regimens employed 3 or 4 divided doses daily, but most current recommendations are for once a day. Three grams per day should not be exceeded. The CDC recommendations do not exceed 2 g per day when given as a daily regimen (see table).

Does pyrazinamide dissolve in water?

Soluble in water (50 mg/ml), methanol (13.8 mg/ml at 25° C), ethanol (5.7 mg/ml at 25° C), chloroform (7.4 mg/ml at 25° C), and DMSO. Melting Point : 189-191° C (lit.)