Should Prednisone Be Spaced out?

It's best to take prednisone as a single dose once a day straight after breakfast. For example if your dose is 30mg daily, it's usual to take 6 tablets (6 x 5mg) all at the same time after breakfast.

How far apart should you space prednisone?

Prednisone comes as a tablet, delayed-release tablet, as a solution (liquid), and as a concentrated solution to take by mouth. Prednisone is usually taken with food one to four times a day or once every other day. Your doctor will probably tell you to take your dose(s) of prednisone at certain time(s) of day every day.

Should prednisone be taken in divided doses?

Single doses are preferred over split doses; however, larger dosages may be split. Some people may be instructed to only take prednisone every other day (alternate day therapy). Take prednisone in the morning, before 9 AM (unless instructed otherwise) to more closely mimic your body's natural secretion of cortisol.