Should Suppositories Be Refrigerated?

Store the suppositories in a cool place to prevent melting. Keep them in the refrigerator if the medication label says to do so.

Do bisacodyl suppositories need to be refrigerated?

If using a bisacodyl suppository, follow these steps:

If the suppository is soft, hold it under cool water or place it in the refrigerator for a few minutes to harden it before removing the wrapper.

How long should I let a suppository sit?

Carefully push the suppository, tapered end first, about 1 inch into your bottom. Close your legs and sit or lie still for about 15 minutes to let it dissolve.