Should Vasopressin Be Titrated?

Vasopressin is not titrated to clinical effect as are other vasopressors and could be thought of more as a replacement therapy and treatment of relative vasopressin deficiency.

How do you titrate vasopressin drip?

The infusion is started at 1-4 mcg/min and titrated up for effect. The usual dose is 2-10 mcg/min. It is a very quick-acting drug with an extremely short half-life. It can be titrated up by 1-2 mcg/min every 20 minutes until the desired effect or hemodynamic stability.

When do you add vasopressin?

Therefore, if there is a role for vasopressin in sepsis, it should probably be started early. Thus, my approach is usually to add a fixed, low-dose vasopressin infusion of 0.03 units/minute when the norepinephrine is running at a low rate (i.e. ~10 mcg/min).