What Activates Gal4
Gal4 Activates Transcription by Recruiting Coactivators and the General Transcription Machinery to Promoter Regions Through Its Activation Domain (Fig 1)...
Gal4 activates transcription by recruiting coactivators and the general transcription machinery to promoter regions through its activation domain (Fig 1). Important questions remain as to what are the functional targets of Gal4 and whether it contacts one or many proteins during the process of recruitment.
What does GAL4 bind to to initiate transcription?
In Mediator, Gal4 binds to the Srb10 and Gal11 subunits, binding Gal11 in two separate regions. Other acidic activators such as yeast Gcn4 have also been found to interact with numerous polypeptides in vitro (6, 15, 35).
Does Gal4 bind to galactose?
Interestingly, however, this effect only occurs when the cells are grown in the presence of glycerol as the main carbon source. By contrast however, in the presence of glucose, GAL4 does not bind to DNA and the addition of galactose has no effect.
Alexander Ross has covered the video game industry for a decade, writing deep dives on game design, esports tournaments, VR developments, and gaming culture.
