What Are 3Rd Generation Antihistamines

Third-generation antihistamines are defined as being metabolites or enantiomers of previously available drugs and can therefore lead to an increase in efficacy and/or safety. In Canada these include: fexofenadine and desloratidine [4].

What is the difference between second and third-generation antihistamines?

Second generation are less likely to reach the brain or be sedating, and third-generation antihistamines are the least likely. However, they all still have the potential to make you feel tired.

How many generations of antihistamines are there?

There are two types of OTC antihistamines: first-generation and second-generation. Both can help allergies. First-generation antihistamines are sometimes used in OTC cold medicines.