What Are Central Alpha Agonists

Central alpha agonists are used to treat hypertension, opioid dependence, alcohol addiction, menopause symptoms, ADHD, spasticity, and fibromyalgia. They work by lowering blood pressure, reducing hot flashes, and relieving withdrawal symptoms, and controlling impulsive behavior.

What drugs are central alpha agonists?

Central alpha-adrenoceptor agonists (methyldopa, clonidine, guanabenz) decrease sympathetic outflow and renin and vasopressin secretion as well as increase parasympathetic activity. These drugs are commonly employed as antihypertensives.

What are central Sympatholytics?

Central sympatholytic drugs reduce blood pressure mainly by stimulating central α(2) -adrenergic receptors in the brainstem centers, thereby reducing sympathetic nerve activity and neuronal release of norepinephrine to the heart and peripheral circulation.