What Are Diastereotopic Protons?
If Replacing Two Protons with a Different Group (X) Gives a Pair of Diastereomers, the Protons Are Called Diastereotopic. .. . the Signals of These Molecules...
If replacing two protons with a different group (X) gives a pair of diastereomers, the protons are called Diastereotopic. ... The signals of these molecules have more complex patterns but what is important for now is to emphasize that diastereotopic protons are not chemically equivalent and give two signals.
What are Diastereotopic hydrogens?
Diastereotopic hydrogens are non-equivalent, so in an NMR spectrum they will appear at different (but possibly similar) chemical shifts. ... Because diastereotopic hydrogens have different chemical shifts, they can undergo spin-spin coupling to each other.
What are Enantiotropic and Diastereotopic protons?
Enantiotopic protons normally have identical chemical shifts. However, when the molecule is placed in a chiral environment (say with an optically active solvent, co-solvent or Lewis acid) then the protons can become diastereotopic. This is in contrast to homotopic protons, which are always identical.
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