What Causes Hyperkeratinization

Hyperkeratinization which occurs because of chronic irritation is due to higher rate of proliferation of the epithelial cells. Decreased keratinization or lack of keratin production is due to failure of the epithelial cells to undergo complete differentiation and maturation to the point of keratin formation.

What causes Hyperkeratinization in acne?

Acne Vulgaris Hyperkeratinization occurs during periods of growth and increased cell turn-over. This increased turn-over of cells results in cohesion of multiple dead skin cells, creating a plug at the epithelial layer.

What causes follicular Hyperkeratinization?

Follicular hyperkeratinization is a key element in the pathogenesis of acne and a main target of retinoid activity. Hyperkeratinization occurs when the cells of the follicle become cohesive and do not shed normally onto the skin’s surface. The result is a microcomedone and subsequent lesions characteristic of acne.