What Causes Keratoderma

What causes palmoplantar keratoderma? Keratoderma may be inherited (hereditary) or, more commonly, acquired. The hereditary keratodermas are caused by a gene abnormality that results in abnormal skin protein (keratin). They may be inherited either by an autosomal dominant or autosomal recessive pattern.

How do you get Keratoderma?

Palmoplantar keratoderma (PPK) can be either acquired during the lifetime (more commonly) or inherited . Acquired PPK may arise due to changes in a person’s health or environment. Inherited forms of PPK are caused by genetic mutations that result in abnormalities of keratin (a skin protein ).

Is Keratoderma cancerous?

Palmoplantar keratoderma (PPK) is a congenital or acquired disorder characterized by the abnormal thickening of the skin of the palms and soles. The thickening can present as a diffuse, focal or punctate pattern. It has been reported to be associated with internal malignancies such as lung and esophageal carcinomas.