What Does Myelophthisis Mean?

Myelophthisis is a form of bone marrow failure that results from the destruction of bone marrow precursor cells and their stroma, which nurture these cells to maturation and differentiation. (See Etiology.)

What causes Myelophthisis?

Myelophthisic anemia is a normocytic, normochromic anemia that occurs when normal marrow space is infiltrated and replaced by nonhematopoietic or abnormal cells. Causes include tumors, granulomatous disorders, lipid storage diseases, and primary myelofibrosis.

What is Leukoerythroblastic blood picture?

Leukoerythroblastic peripheral blood smear showing the presence of nucleated red cells and immature white cells. This pattern occurs with marrow replacement, usually due to fibrosis that may be idiopathic (eg, primary myelofibrosis) or reactive to conditions such as metastatic cancer.