What Factor Is Thrombin

Prothrombin (factor II) is a soluble 72-kDa protein that is produced by the liver. It is activated to thrombin (factor IIa) via enzymatic cleavage of two sites by activated FX (FXa). Activated thrombin leads to cleavage of fibrinogen into fibrin monomers that, upon polymerization, form a fibrin clot.

Is thrombin a factor V?

Activated factor X is another factor upstream from factor V in the coagulation cascade. Thrombin is a downstream product of activated factor V and activated factor X activity and acts in a positive feedback manner to further increase the production of itself.

Is thrombin a tissue factor?

Available structuresPDBshowList of PDB id codes