What Inhibits Atp Synthesis

The mode of inhibition by efrapeptin during ATP synthesis is competitive with ADP and phosphate (83). Efrapeptin also binds to the nonmitochondrial ATP synthase of endothelial cells and inhibits extracellular ATP synthesis (17).

What can inhibit the ATP synthase?

Antibiotics efrapeptins and aurovertins inhibit both synthesis and hydrolysis of ATP by ATP synthase. The efrapeptins bind to ATP synthase at a site extending from the rotor, across the central cavity of the enzyme, into the specific β-subunit catalytic site.

What is an ATP inhibitor?

ATPases are enzymes which catalyze the hydrolysis of ATP to form ADP, thus releasing energy which can be used to drive other reactions and transmembrane ion transport. …