What Is a 3A4 Inhibitor

Key Messages. CYP3A4 is responsible for the metabolism of more than 50% of medicines. … Potent inhibitors of CYP3A4 include clarithromycin, erythromycin, diltiazem, itraconazole, ketoconazole, ritonavir, verapamil, goldenseal and grapefruit. Inducers of CYP3A4 include phenobarbital, phenytoin, rifampicin, St.

What happens when you inhibit CYP3A4?

1-3 In addition, the CYP enzymes are commonly associated with causing many clinically relevant drug-drug interactions. … 1-4 The inhibition of CYP3A4 can result in the accumulation of parent drug concentrations that can put the patient at increased risk for side effects and possible toxicity.

What does a CYP inhibitor do?

CYP450 inhibitors are used to minimize or prevent such reactions. Drugs are metabolized in many sites of our body; however, the liver is the primary organ for drug metabolism. … CYP450 inhibition can be categorized as: Reversible inhibition (a result of rapid association and dissociation between drugs and CYP enzymes)