What Is Anchorage Dependence?

Anchorage dependence can be defined as an increase in proliferation which is seen when cells are allowed to attach to a solid surface. ... Thus in 5% serum, the area of attached is 3 times greater than suspended cells, while in 66% serum, the areas of attached and suspended cells are equal.

Why is anchorage dependence important?

Anchorage dependence of cellular growth and survival prevents inappropriate cell growth or survival in ectopic environments, and serves as a potential barrier to metastasis of cancer cells.

What is anchorage dependence cancer cells?

This attachment is responsible for what was termed “anchorage dependence.” Normal cells that are detached from their binding to the ECM undergo apoptosis, whereas tumor cells that are less dependent on this attachment are free to proliferate, wander, and invade tissues.