What Is Blast Crisis in Aml?

Listen to pronunciation. (blast KRY-sis) A phase of chronic myelogenous leukemia in which tiredness, fever, and an enlarged spleen occur during the blastic phase, when more than 30% of the cells in the blood or bone marrow are blast cells

What are AML blasts?

Most patients with AML have too many immature white cells in their blood, and not enough red blood cells or platelets. Many of the white blood cells may be myeloblasts (often just called blasts), which are very early forms of blood-forming cells that are not normally found in the blood.

What does a blast crisis result in?

Blast Crisis: A critical increase in circulating leukocytes, or leukostasis, leads to blood hyperviscosity and ultimately decreased tissue perfusion via the formation of white cell plugs in the microvasculature.