What Is Dexdomitor

(dexmedetomidine hydrochloride)

DEXDOMITOR is indicated for use as a sedative and analgesic in dogs and cats to facilitate clinical examinations, clinical procedures, minor surgical procedures and minor dental procedures. DEXDOMITOR also is effective as a preanesthetic in dogs and cats prior to general anesthesia.

What kind of drug is Dexdomitor?

DEXDOMITOR (dexmedetomidine hydrochloride) is a synthetic alpha 2-adrenoreceptor agonist with sedative and analgesic properties.

What are the side effects of Dexdomitor?

Commonly reported side effects of dexmedetomidine include: bradycardia, hypotension, agitation, hypertension, nausea, and tachycardia. Other side effects include: vomiting, and xerostomia. See below for a comprehensive list of adverse effects.

Is Dexdomitor used in humans?

Dexmedetomidine was approved by the Food and Drug Administration at the end of 1999 for use in humans as a short-term medication (

Does Dexdomitor lower blood pressure?

During a continuous infusion of dexmedetomidine (0.2–0.7 µg/kg per hour), patients typically experience a slight decrease in blood pressure, heart rate, and cardiac output. This effect is mediated by sympatholysis, as indicated by the fact that patients taking β-blockers do not experience heart rate slowing.

How long does it take for Dexdomitor to wear off?

The peak sedative and analgesic effects are reached within 30 minutes after administration. Sedation lasts for at least 120 minutes post administration and analgesia lasts for at least 90 minutes. Spontaneous recovery occurs within 3 hours.

How does precedex make you feel?

The most common adverse reactions to dexmedetomidine are hypertension, hypotension, nausea, bradycardia, hypoxia, and anemia. 1 Overdoses of dexmedetomidine can lead to second- and third-degree heart block, which generally resolves spontaneously.

Is ANTISEDAN a controlled substance?

Advantages: Produces analgesia of short duration; can be combined with Ketamine to produce adequate surgical anesthesia in many species; effects can be reversed with a subcutaneous α2 antagonists injection such as Atipamezole; not a DEA controlled drug; not irritating when administered IM or IP.

How quickly does dexmedetomidine work?

Its onset of action is less than 5 minutes and the peak effect occur within 15 minutes. As the pharmacologic effects of dexmedetomidine can be reversed by the α2-AR antagonist atipamezole,[44] dexmedetomidine provides a titratable form of hypnotic sedation that can be readily reversed.

Why is dexmedetomidine better than clonidine?

Dexmedetomidine is 8 times more specific for α2 receptors than clonidine and the improved specificity for the α2 adrenoreceptors, especially for the 2A subtype may make it to be a much more effective sedative than clonidine. [10] Our finding of dexmedetomidine treated patients is in concurrence with previous studies.

How long does butorphanol last in a dog?

Butorphanol is a short-acting drug and will generally be out of your pet’s system within 24 hours, although the effects may last longer if your pet has decreased liver or kidney function. Side effects include sedation, excitement, respiratory depression, ataxia, anorexia, or rarely diarrhea.

What type of drug is milrinone?

Milrinone is a vasodilator that is used as a short-term treatment for life-threatening heart failure. Milrinone may also be used for purposes not listed in this medication guide.

Does precedex make you sleepy?

Precedex (dexmedetomidine hydrochloride) is an alpha2-adrenergic agonist with sedative properties used for short-term intravenous sedation.

What is the difference between propofol and precedex?

Precedex and propofol are different types of sedatives. Precedex is an alpha2-adrenergic agonist and propofol is a sedative-hypnotic.

What happens if you give too much precedex?

What happens if I overdose on Precedex (Dexmedetomidine)? Since this medicine is given by a healthcare professional in a medical setting, an overdose is unlikely to occur. In the event of an overdose, medical care providers in an intensive care setting are able to quickly treat any symptoms that may occur.

Can you use atropine with Dexdomitor?

Conclusions and clinical relevance: Administration of atropine at 0.02 mg/kg, IM, with dexmedetomidine at 10 μg/kg, IM, resulted in an increase in mean arterial blood pressure and heart rate; deleterious cardiac arrhythmias were also observed. Use of atropine with dexmedetomidine is not recommended in dogs.

Is Dexdomitor a vasoconstrictor?

Dexmedetomidine‐induced vasoconstriction is mediated by vascular smooth muscle alpha‐2B receptors 3. This vasoconstrictive effect is rapid (t½ for equilibration 2.16 min). Most other alpha‐2 agonist‐mediated effects, such as sedation and sympatholytic effects, may take 10–15 min to approach their maximum 20, 21.

Does precedex affect breathing?

Dexmedetomidine provides important postsurgical analgesia and appears to have no clinically important adverse effects on respiration in the surgical patient who requires intensive care.

Is Dexdomitor a tranquilizer?

Dexmedetomidine is approved for use by the US Food and Drug Administration as a sedative for less than 24 hours duration.

How is Dexdomitor given?

DEXDOMITOR is also indicated for use as a preanesthetic to general anesthesia in dogs. DOSAGE AND ADMINISTRATION: Dogs: DEXDOMITOR produces sedation and analgesia when administered intramuscularly (IM) at a dose of 500 mcg/m2, or intravenously (IV) at a dose of 375 mcg/m2.