What Is Dhtr

Delayed hemolytic transfusion reactions (DHTR) are caused by an anamnestic antibody response in the recipient precipitated by re-exposure to a non-ABO red cell antigen previously introduced by transfusion, transplantation or pregnancy.

How do you treat DHTR?

Symptomatic patients experiencing DHTR can be immediately treated with intravenous immunoglobulin (IVIg), adding erythropoietin (EPO) if the DHTR is also associated with reticulocytopenia. Prophylactic anticoagulation is administered to lower the risk of thrombosis associated with EPO administration.

What is a hemolytic reaction?

A hemolytic transfusion reaction is a serious complication that can occur after a blood transfusion. The reaction occurs when the red blood cells that were given during the transfusion are destroyed by the person’s immune system. When red blood cells are destroyed, the process is called hemolysis.