What Is Hepatic Ketogenesis

Hepatic ketogenesis is activated in states of high fatty acid and diminished carbohydrate availability and/or when circulating insulin concentrations are very low (17–20).

What is liver Ketogenesis?

At the same time, ketogenesis, i.e. the production by the liver of the ketone bodies β-hydroxybutyrate and acetoacetate (AcAc), is a physiologically important process to produce an alternative metabolic source of energy during the neonatal period, starvation or prolonged physical effort [30].

What stimulates ketogenesis in the liver?

Ketogenesis can be upregulated by hormones such as glucagon, cortisol, thyroid hormones, and catecholamines by causing a more significant breakdown of free fatty acids, thus increasing the amount available to be used in the ketogenic pathway. However, insulin is the primary hormonal regulator of this process.