What Is Imatinib Target
Imatinib Is a Targeted Cancer Drug (Biological Therapy) and Is Also Known by Its Brand Name Glivec (Pronounced Glee-Vec). It Is a Treatment for Many Different...
Imatinib is a targeted cancer drug (biological therapy) and is also known by its brand name Glivec (pronounced glee-vec). It is a treatment for many different types of cancer.
How does Gleevec target cancer cells?
Gleevec, known generically as imatinib, works by slowing or stopping the growth of certain cancer cells. Gleevec inhibits (or blocks) specific enzymes in the body called tyrosine kinases. Tyrosine kinase enzymes are involved in many cell functions, including cell signaling (communication), growth, and division.
How does imatinib target BCR-ABL?
Imatinib binds to Abl domain via six hydrogen bond interactions. This stabilizes the imatinib Bcr-Abl complex and prevents ATP from reaching its binding site.
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