What Is Isogenic Strain?

Isogenic strains (inbred strains and F1 hybrids) are like immortal clones of genetically identical individuals. The same genotype can be reproduced indefinitely. They have already made a substantial contribution to biomedical research.

What is meant by inbred strain?

An inbred strain is a population of animals that result from a process of at least 20 sequential generations of brother–sister matings. The resultant animals are essentially clones of each other at the genetic level.

What is the difference between inbred and outbred mice strain?

Genetically, there are two major classes of laboratory mice: inbred and outbred. Inbred mice are genetically homogeneous and there is very little variation or heterogeneity within a pure inbred strain. ... Outbred mice are bred specifically to maximize genetic diversity and heterozygosity within a population.