What Is Limbal Stem Cell Deficiency?
Limbal Stem Cell Deficiency Is a Disease in Which the Stem Cell Functions of the Limbus and the Barrier Function of the Limbus Fail [12]. Because of Failure of...
Limbal stem cell deficiency is a disease in which the stem cell functions of the limbus and the barrier function of the limbus fail [12]. Because of failure of corneal epithelial healing from limbal stem cells, as a result of either loss or dysfunction, corneal epithelial defects appear and fail to heal normally.
What causes stem cell deficiency?
Etiology of limbal stem cell deficiency
Common causes in acquired LSCD include chemical and thermal burns, multiple ocular surgeries involving the limbal region, contact lens wear, and ocular surface inflammatory diseases.
What happens when the limbus is damaged?
If the stem cells at the limbus are damaged, the renewal process is interrupted. The complete or partial loss of these stem cells — limbal stem-cell deficiency (LSCD) — allows the opaque conjunctiva to grow over the cornea. This can lead to intense pain and, in the most-severe cases, blindness.
Marcus Vance is a cybersecurity auditor and technology writer dedicated to educating the public about online safety, data privacy regulations, enterprise security, and emerging cyber threats.
