What Is Morrison Syndrome
This Syndrome of Watery Diarrhea Associated with Hypokalemia and Achlorhydria Was First Described by Verner and Morrison, in 1958, and Has Been Assumed to Be...
This syndrome of watery diarrhea associated with hypokalemia and achlorhydria was first described by Verner and Morrison, in 1958, and has been assumed to be due to hypersecretion of VIP. In children, as well as in adult patients, the most likely explanation for persistent secretory diarrhea may be an occult VIPoma.
Why does VIPoma cause flushing?
Almost 8% of patients exhibit facial flushing, connected with prostaglandin production by the tumour. The profound glycogenolytic effects of VIP on the liver lead to diminished glucose intake by tissues and consequent hyperglycemia (18).
What causes VIPoma?
The VIPoma syndrome is caused by excessive, unregulated secretion of vasoactive intestinal polypeptide (VIP) by the tumor. However, other substances, such as prostaglandin E2, may occasionally be secreted by the tumors [12].
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