What Is Nmba Impurity
Nitrosamine Impurities N-Nitrosodimethylamine (Ndma), N-Nitrosodiethylamine (Ndea) and N-Nitroso- N-Methyl-4-Aminobutyric Acid (Nmba), Found in Some...
Nitrosamine impurities N-Nitrosodimethylamine (NDMA), N-Nitrosodiethylamine (NDEA) and N-Nitroso- N-methyl-4-aminobutyric acid (NMBA), found in some angiotensin II receptor blocker (ARB) medicines, have been the driver for recent product recalls and the subject of a US Food and Drug Administration (FDA) focus to ensure …
What impurities were found in losartan?
The recalled losartan potassium tablets made by Hetero Labs and distributed by Camber Pharmaceuticals contain the impurity, N-Nitroso-N-methyl-4-aminobutyric acid (NMBA). The impurity is a known animal and potential human carcinogen.
Where does nitrosamine come from?
Nitrosamines are formed by a reaction between nitrates or nitrites and certain amines. Nitrosamines and/or their precursors can be found in diverse consumer products such as processed meats, alcoholic beverages, cosmetics, and cigarette smoke.
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