What Is the Clonal Selection Hypothesis

Key Terms. clonal selection: An hypothesis which states that an individual lymphocyte (specifically, a B cell) expresses receptors specific to the distinct antigen, determined before the antibody ever encounters the antigen. Binding of Ag to a cell activates the cell, causing a proliferation of clone daughter cells.

What are the steps of clonal selection?

Clonal selection of lymphocytes: 1) A hematopoietic stem cell undergoes differentiation and genetic rearrangement to produce 2) immature lymphocytes with many different antigen receptors. Those that bind to 3) antigens from the body’s own tissues are destroyed, while the rest mature into 4) inactive lymphocytes.

What is clonal selection a level biology?

Clonal selection: ​The process of matching the antigens on an antigen presenting cells with the antigen receptors on B and T lymphocytes.