What Is the Difference Between Boniva and Prolia?

Are Boniva and Prolia the Same Thing? Prolia (denosumab) and Boniva (ibandronate) are used to prevent and treat bone loss (osteoporosis) in women who are at high risk for bone fracture after menopause. Prolia and Boniva belong to different drug classes. Prolia is a monoclonal antibody and Boniva is a bisphosphonate.

What is the best and safest treatment for osteoporosis?

Bisphosphonates are usually the first choice for osteoporosis treatment. These include: Alendronate (Fosamax), a weekly pill. Risedronate (Actonel), a weekly or monthly pill.

Why was Boniva taken off the market?

There are concerns about the long-term safety of bisphosphonates (such as Boniva) as long-term use has been associated with atypical femur fractures, osteonecrosis of the jaw, and esophageal cancer. The risk of osteonecrosis of the jaw is greater in those who have received chemotherapy, radiation, or steroids.