What Is Vip Disease
A Vipoma Is a Non-Beta Pancreatic Islet Cell Tumor Secreting Vasoactive Intestinal Peptide (Vip), Resulting in a Syndrome of Watery Diarrhea, Hypokalemia, and...
A vipoma is a non-beta pancreatic islet cell tumor secreting vasoactive intestinal peptide (VIP), resulting in a syndrome of watery diarrhea, hypokalemia, and achlorhydria (WDHA syndrome).
What causes high VIP levels?
A very high level is usually caused by a VIPoma . This is an extremely rare tumor that releases VIP. VIP is a substance found in cells throughout the body. The highest levels are normally found in cells in the nervous system and gut.
How does VIP cause diarrhea?
VIP is a 28 amino acid polypeptide that binds to high affinity receptors on intestinal epithelial cells, leading to activation of cellular adenylate cyclase and cAMP production. This results in net fluid and electrolyte secretion into the lumen, resulting in secretory diarrhea and hypokalemia [12,13].
David Miller brings 15 years of experience in global economics, personal finance strategy, and market dynamics. He specializes in turning complex economic trends into actionable insights for everyday readers.
