What Lgmd Stand for?

Limb-girdle muscular dystrophies (LGMD) are a group of rare progressive genetic disorders that are characterized by wasting (atrophy) and weakness of the voluntary muscles of the hip and shoulder areas (limb-girdle area). Muscle weakness and atrophy are progressive and may spread to affect other muscles of the body.

How many types of LGMD are there?

Around 19 forms of LGMD have been identified, each of which occurs because of mutations in different genes involved in the production of certain muscle proteins. Even though many genes that cause LGMD have been identified, other genes that are thought to be involved in rarer forms of LGMD have yet to be identified.

What causes limb-girdle muscular dystrophy?

LGMD is caused by mutations of genes that result in abnormal function of proteins in muscles, thereby causing progressive muscle weakness. The inheritance pattern of LGMD varies and different genetic defects may result in the same clinical symptoms in different patients.