What Mutation Causes Hypotrichosis?

Autosomal recessive hypotrichosis can be caused by mutations in the LIPH, LPAR6, or DSG4 gene. These genes provide instructions for making proteins that are involved in the growth and division (proliferation) and maturation (differentiation) of cells within hair follicles .

What causes hypotrichosis?

The leading cause of hypotrichosis is genetics. However, there are several other reasons that the loss of eyelashes can occur. These include aging, chemotherapy, or the nervous habit of pulling on the eyelash.

Is congenital hypotrichosis genetic?

The majority of hypotrichoses are due to genetic aberrations or defects of embryonic development. There are hundreds of types of genetic hypotrichoses. Often, affected individuals have other physical or mental problems beyond a lack of hair.