What's the Best Antihistamine for Itchy Skin?

Benadryl. The first-generation antihistamine diphenhydramine is the main active ingredient in Benadryl. Benadryl helps relieve runny nose, sneezing, itchy or watery eyes, and nose or throat itching. These symptoms may be due to hay fever, other upper respiratory allergies, or the common cold.

Which is the best antihistamine for itchy skin?

A nonprescription oral antihistamine, such as loratadine (Alavert, Claritin, others), cetirizine (Zyrtec Allergy, others) or diphenhydramine (Benadryl Allergy, others), may help relieve itching.

Will an antihistamine help with itchy skin?

Histamines are chemicals in the body that cause allergy symptoms, including itching. An antihistamine is a common treatment for allergic reactions. But many antihistamine drugs can make you sleepy, so they're best used before bed. Also, oral antihistamines tend to work best if your itchy skin is caused by allergies.