When Benadryl Doesn't Work for Allergic Reaction?

If antihistamines don't help, your doctor might prescribe a corticosteroid. These drugs calm the immune system. That can make your hives less severe. You can get them in a shot or a pill.

What happens if hives Don't go away with Benadryl?

Call Your Doctor If:

Severe hives not better after 2 doses of Benadryl. Itch not better after 24 hours on Benadryl.

Can Benadryl make allergic reaction worse?

There have been no studies to suggest that humans experience the same issue. Sawlani agrees that OTC meds like antihistamines and nasal sprays, and certainly eye drops, “should not have a significant clinical impact on your immune system.” Bassett explains that it's probably not your drugs that are to blame.

Alexander Ross

Alexander Ross

Gaming, Esports & Interactive Media Writer

Alexander Ross has covered the video game industry for a decade, writing deep dives on game design, esports tournaments, VR developments, and gaming culture.