When Do Frameshift Mutations Occur?

Frameshift mutations arise when the normal sequence of codons is disrupted by the insertion or deletion of one or more nucleotides, provided that the number of nucleotides added or removed is not a multiple of three.

Where do frameshift mutations occur?

Frameshift mutations can occur either by deleting or inserting the nucleotide in the nucleic acid (Figure 3). Deletion frameshift mutation, wherein one or more nucleotides are deleted in a nucleic acid, resulting in the alteration of the reading frame, i.e., reading frameshift, of the nucleic acid.

How do point mutations and frameshift mutations occur?

Some scientists recognize another type of mutation, called a frameshift mutation, as a type of point mutation. Frameshift mutations can lead to drastic loss of function and occur through the addition or deletion of one or more DNA bases.