When Does Autodigestion Occur?

Autodigestion describes a process whereby pancreatic enzymes destroy its own tissue leading to inflammation. The inflammation may be sudden or ongoing.

How does autodigestion happen?

Autodigestion describes a process whereby pancreatic enzymes destroy its own tissue leading to inflammation. The inflammation may be sudden (acute) or ongoing (chronic). Acute pancreatitis usually involves a single “attack,” after which the pancreas returns to normal.

What causes autodigestion of the pancreas?

Inflammation triggers autodigestion

Normally, pancreatic enzymes don't become active until they leave the pancreas. During pancreatitis, however, inflammation delays release of activated enzymes, giving them time to attack pancreatic cells and leak into surrounding tissues. This process causes more inflammation.