When Does Axillary Freckling Appear?
The Majority of Affected Children Will Show Axillary or Inguinal Freckling by the Age of 2, and by 11 Year's Most Children Will Have 2 or More Neurofibromata...
The majority of affected children will show axillary or inguinal freckling by the age of 2, and by 11 years most children will have 2 or more neurofibromata of any type or 1 plexiform neurofibroma (slow-growing tumours that involve multiple nerves and fascicles).
Is axillary freckling normal?
Axillary or inguinal freckles are rarely present at birth, but appear during childhood through adolescence. Subcutaneous or cutaneous neurofibromas are seen rarely in young children but appear over time in older children, adolescents, and adults.
What causes axillary freckling?
The Crowe sign or Crowe's sign is the presence of axillary (armpit) freckling in people with neurofibromatosis type I (von Recklinghausen's disease). These freckles occur in up to 30% of people with the disease and their presence is one of six diagnostic criteria for neurofibromatosis.
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