When Does Clonal Expansion Occur?

You can tell that clonal expansion is occurring when you feel tender bumps (swollen lymph nodes) in your neck or other areas. When lymphocytes multiply during clonal expansion, some of them are destined to live on as memory T and B cells.

How does clonal expansion happen?

Clonal expansion is the process by which daughter cells arise from a parent cell. During B cell clonal expansion, many copies of that B cell are produced that share affinity with and specificity of the same antigen.

Where does clonal selection occur?

This activation occurs in secondary lymphoid organs such as the spleen and the lymph nodes. In short, the theory is an explanation of the mechanism for the generation of diversity of antibody specificity.