When Is Amylin Released?

Amylin is a 37-amino-acid peptide that is co-secreted with insulin from the pancreatic beta cells. Therefore, unlike true enteroendocrine peptides, amylin is secreted primarily in response to postabsorptive stimulation of pancreatic beta cells by glucose.

When is amylin secreted?

Amylin is secreted in response to nutrient stimuli and displays a 24-h profile similar to that of insulin (9). Also, amylin has been shown to be secreted in a high frequency pulsatile manner, similar to insulin (10).

Do beta cells secrete amylin?

Amylin is co-stored and co-secreted with insulin by pancreatic islet β-cells. Amylin inhibits food intake, delays gastric emptying, and decreases blood glucose levels, leading to the reduction of body weight.