When Is Hexokinase Active?
Hexokinase Undergoes an Induced Fit Conformational Change When Glucose Binds. This Conformational Change Prevents the Hydrolysis of Atp, and Is Allosterically...
Hexokinase undergoes an induced fit conformational change when glucose binds. This conformational change prevents the hydrolysis of ATP, and is allosterically inhibited by physiological concentrations of glucose-6-phosphate the product.
How is hexokinase activated?
Kinetics and Inhibition of Hexokinase
Hexokinase activates glycoloysis by phosphorylating glucose. ... Tissues where hexokinase is present use glucose at low blood serum levels. G6P inhibits hexokinase by binding to the N-terminal domain(this is simple feedback inhibition). It competitively inhibits the binding of ATP [8].
What activates hexokinase in glycolysis?
Hexokinase, the enzyme catalyzing the first step of glycolysis, is inhibited by its product, glucose 6-phosphate. ... In turn, the level of glucose 6-phosphate rises because it is in equilibrium with fructose 6-phosphate. Hence, the inhibition of phosphofructokinase leads to the inhibition of hexokinase.
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