When Should Vancomycin Trough Be Drawn?

Trough: just before 4th dose of a new regimen (prior to 3rd dose for dosing intervals ≥ 24 hours or changing renal function) - Trough levels should be obtained within 30 minutes before the next scheduled dose. - Weekly vancomycin levels should be obtained for long-term vancomycin use with stable renal function.

When should trough levels be drawn?

The trough level is the lowest concentration in the patient's bloodstream, therefore, the specimen should be collected just prior to administration of the drug. The peak level is the highest concentration of a drug in the patient's bloodstream.

When do you draw vancomycin after hemodialysis?

Generally, most people wait 4-6 hours after the end of dialysis before checking post-HD vancomycin levels to avoid falsely low results.